Rat meningeal and brain microvasculature pericytes co-express the vesicular glutamate transporters 2 and 3
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چکیده
منابع مشابه
Distribution of vesicular glutamate transporters in the human brain
Glutamate is the major excitatory transmitter in the brain. Vesicular glutamate transporters (VGLUT1-3) are responsible for uploading glutamate into synaptic vesicles. VGLUT1 and VGLUT2 are considered as specific markers of canonical glutamatergic neurons, while VGLUT3 is found in neurons previously shown to use other neurotransmitters than glutamate. Although there exists a rich literature on ...
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developed that BNP1 might have alternative, or at least additional roles. First, mutations in a BNP1 homolog in C. elegans (eat-4) were noted to cause presynaptic An essential step in chemical synaptic transmission in-deficits in glutamatergic transmission (Berger et al., volves concentration of neurotransmitter into synaptic 1998). Second, immunocytochemical studies of BNP1 vesicles, allowing ...
متن کاملImmunohistochemical localization of candidates for vesicular glutamate transporters in the rat brain.
Vesicular glutamate transporter 1 (VGluT1) is one of the best markers for glutamatergic neurons, because it accumulates transmitter glutamate into synaptic vesicles. Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter (DNPI) shows 82% amino acid identity to VGluT1, and is another candidate for vesicular glutamate transporters. Here, we report the immunocytochemical loca...
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Vesicular glutamate transporters (VGLUTs) are essential to glutamatergic synapses and determine the glutamatergic phenotype of neurones. The three known VGLUT isoforms display nearly identical uptake characteristics, but the associated expression domains in the adult rodent brain are largely segregated. Indeed, indirect evidence obtained in young VGLUT1-deficient mice indicated that in cells th...
متن کاملDopaminergic axons in different divisions of the adult rat striatal complex do not express vesicular glutamate transporters.
Midbrain dopamine neurons signal rapid information about rewards and reward-related events. It has been suggested that this fast signal may, in fact, be conveyed by co-released glutamate. Evidence that dopamine neurons co-release glutamate comes largely from studies involving cultured neurons or tissue from young animals. Recently, however, it has been shown that this dual glutamatergic/dopamin...
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ژورنال
عنوان ژورنال: Neuroscience Letters
سال: 2008
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2008.01.082